背景:
方法:
Subject and methodological characteristics of the in vivo imaging studies of TSPO binding in schizophrenia compared with healthy controls (BP = 6; VT = 6)
Author Year | Patients/controls (n) | Patient age mean (SD) years | Diagnosis | Duration of illness mean (SD) years | Current antipsychotic treatment? | Region(s) of interest (ROI) | Tracer | Genotyping | Outcome measures | Results in patients compared with controls |
---|---|---|---|---|---|---|---|---|---|---|
van Berckel et al. (2008) | 10/10 | 24 (2) | Recent-onset schizophrenia (<5 years of illness) | 3.1 (1.7) | Yes | Total grey matter | [11C]-PK11195 | No | BP−P | ↑ |
Doorduin et al. (2009) | 7/8 | 31.2 (7.2) | Recent-onset schizophrenia (<5 years of illness)/psychotic disorder not otherwise specified | 5.4 (5.4) | Yes | Total grey matter Frontal Cx/occipital Cx/temporal Cx/parietal Cx/basal ganglia/thalamus/hippocampus/midbrain/cerebellum/pons | [11C]-PK11195 | No | BP | ↑ (Hippocampus) ↔ (total grey matter and all ROI) |
Takano et al., 2010 | 14/14 | 43.8 (7.4) | Chronic Schizophrenia | 18.8 (12.2) | Yes | Total cortical regions Medial frontal cortex, dorsolateral frontal cortex, medial temporal cortex, lateral temporal cortex, parietal cortex, occipital cortex, thalamus, striatum, cerebellum, anterior cingulate cortex and posterior cingulate cortex | [11C]-DAA1106 | No | BPND | ↔ (All regions) |
Kenk et al. (2015) | 18/27 | 42.6 (14.1) | Chronic schizophrenia | 14.8 (8.8) | Yes | Hippocampus/mPFC Cx/temporal Cx/DLPFC Cx/V striatum/corpus callosum/cingulum/SLF/PLIC | [18F]-FEPPA | Yes | VT | ↔ (All regions) |
Bloomfield et al. (2016a, 2016b) | 14/14 | 24.3 (5.4) | Ultra high risk for psychosis | N/A | No | Total grey matter/frontal Cx/temporal/cerebellum/brain stem | [11C]-PBR28 | Yes | DVR VT | DVR: ↑ (total grey matter, frontal Cx, temporal Cx); ↔ (all other regions) VT: ↔ (all regions) |
14/14 | 47.0 (9.3) | Chronic schizophrenia | Not specified | Yes | Total grey matter/frontal Cx/temporal Cx/cerebellum/brain stem | DVR: ↑ (total grey matter, frontal Cx, temporal Cx); ↔ (all other regions) VT: ↔ (all regions) | ||||
Hafizi et al. (2016) | 19/20 | 27.5 (6.7) | First-episode psychosis: schizophreniform disorder/delusional disorder/schizophrenia/psychosis NOS | 2.8 (3.3) | No | Whole brain Total grey matter DLPFC/mPFC/Temporal Cx/hippocampus | [18F]-FEPPA | Yes | VT DVR | ↔ (All regions) |
van der Doef et al. (2016) | 19/17 | 26 (4) | First-episode psychosis (<5 years of illness) | 1.3 (1.1) | Yes | Total grey matter Frontal Cx/temporal Cx/parietal Cx/striatum/thalamus | [11C]-PK11195 | No | BPND | ↔ (All regions) |
Coughlin et al. (2016) | 12/14 | 24.1 (3.1) | Recent-onset schizophrenia (<5 years of illness) | 2.2 (1.4) | Yes | Total grey matter Insula Cx/cingulate Cx/parietal Cx/frontal Cx/temporal Cx/occipital Cx/hippocampus/amygdala | [11C]- DPA-713 | Yes | VT | ↔ (All regions) |
Holmes et al. (2016) | 8/16 | 33 (9) | Schizophrenia | 15 (7) | Yes | DLPFC/VLPFC/OFC/anterior cingulate Cx/parietal Cx | [11C]-PK11195 | No | BPND | ↑ DLPFC, VLPFC and ACC ↔ (all other regions) |
8/16 (Shared control group) | Schizophrenia | 4 (2) | No | ↔ (all other regions) | ||||||
Collste et al. (2017) | 16/16 | 28.5 (8.4) | First-episode psychosis: schizophrenia/schizophreniform psychosis/psychosis NOS/brief psychosis | 7.9 (9.6) | No | Total grey matter White matter/frontal Cx/temporal Cx/hippocampus | [11C]-PBR28 | Yes | VT | ↓ (Total grey matter, frontal Cx, temporal Cx, hippocampus) ↔ (white matter) |
Di Biase et al. (2017) | 18/15 | 20.6 (5.5) | Recent-onset schizophrenia | 1.5 (1.0) | Yes | Dorsal frontal Cx/orbital frontal Cx/anterior cingulate Cx/medial temporal Cx/thalamus/insular Cx | [11C]-PK11195 | No | BPND | ↔ (All regions) |
15/12 | 35.2 (6.6) | Chronic schizophrenia | 13.6 (8.8) | Yes | Dorsal frontal Cx/orbital frontal Cx/anterior cingulate Cx/medial temporal Cx/thalamus/insular Cx | [11C]-PK11195 | No | BPND | ↔ (All regions) | |
Ottoy et al., (2018) | 11/17 | 30.0 (7.0) | Chronic schizophrenia | N/A | Yes | Cortical grey matter/cortical white matter/cerebellum/brainstem/thalamus/basal ganglia/hippocampus/amygdala | [18F]-PBR111 | Yes | VT | ↔ (All regions) |
结论: